Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients

Authors

  • Ali Rafinejad Department of Immunology, School of Medicine, Tehran University of Medical Sciences
  • Bagher Larijani Endocrinology and Metabolism Research Center, Tehran, Iran.
  • Farideh Khosravi Department of Immunology, School of Medicine, Tehran University of Medical Sciences
  • Mohammad Hossein Niknam Department of Immunology, School of Medicine, Tehran University of Medical Sciences
Abstract:

Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D.   Objective: IFN-¹ polymorphism was investigated in T1D and compared with normal controls.   Methods: Thirty patients suffering from T1D and 40 normal controls were studied simultaneously using PCR technique. IFN-   ¹ gene was evaluated at position 5’UTR +5644. Results: There was a significant difference between patient and control groups in TT genotype (P

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Journal title

volume 1  issue 2

pages  130- 132

publication date 2004-09-01

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